Project Page Views: [ 634 ]
| Project Metadata Element | Details |
| Project Title | Novel alcohol dehydrogenases for the synthesis of chiral alcohols |
| Research Area | Water |
| Project Acronym | |
| Principal Investigator or Lead Irish Partner | Francesca Paradisi |
| Lead Institution or Organisation | University College Dublin (UCD) |
| Lead Country | Ireland |
| Latitude, Longitude (of Lead Institution) | 53.30859, -6.22577 |
| Lead Funding Entity | Environmental Protection Agency |
| Approximate Project Start Date | 04/09/2006 |
| Approximate Project Finishing Date | 05/01/2011 |
| Project Website (if any) | |
| Links to other Web-based resources | |
| Project Keywords | Enzymes; Pharmaceutical Industry; Tolerance; Green Chemistry |
| Project Abstract | Enzymes from extremophiles (organisms which live in extreme environments) have unusual characteristics of stability and tolerance to harsh working reaction conditions making them extremely appealing for bio-applications and industrial scale-ups. The aim of this project is to clone an alcohol dehydrogenase (ADH) from Halobacterium salinarum an archaebacterium which thrives in highly-salted water to investigate its properties. ADHs can reduce ketones to secondary chiral alcohols which together with their derivatives are in great demand from the pharmaceutical industry. This project targets the production of valuable molecules via bio-catalysis employing a robust biocatalyst (enzyme) with minimal impact on the environment (green chemistry). |